More evidence is being launched regarding the link between Vitamin D deficiency and MS. My recommendation remains to have your levels tested, including screening with Vit. D25OH, but also Vit. D1,25-diOH if you seem to require elevated supplementation (over 4000 IU daily) to achieve normal levels of Vit. D. There are some people who over-convert to Vit. D1,25diOH which can put them at risk for bone degeneration. This is often overlooked–at least in part, because insurance doesn’t like to cover either of these tests.